Focus on lens connexins
نویسندگان
چکیده
منابع مشابه
Connexins, Cell Proliferation and Second Messengers in the Crystalline Lens
Gap junctions are responsible for the direct coupling of cells that enables intercellular exchange of ions, small metabolites and second messengers. Lens epithelial cells are well coupled (Fig.1a) by connexin (Cx) channels that constitute the structural subunits of gap junctions.1,2 Surprisingly, epithelial cell proliferation during the early postnatal period (Fig.1b) was found to be profoundly...
متن کاملConnections Between Connexins, Calcium, and Cataracts in the Lens
There is a good deal of evidence that the lens generates an internal micro circulatory system, which brings metabolites, like glucose, and antioxidants, like ascorbate, into the lens along the extracellular spaces between cells. Calcium also ought to be carried into the lens by this system. If so, the only path for Ca2+ to get out of the lens is to move down its electrochemical gradient into fi...
متن کاملCrystalline Lens With Focus
Methods. Scheimpflug slit-lamp photography, as well as a variety of standard ophthalmologic methods, was used to collect information about lens and anterior segment sagittal dimensions in a population of 82 adults with refractive error < 12.01 diopters and at least 0.25 diopter of accommodation for subjects 18 to 70 years of age. Data were analyzed statistically for dependence on accommodation,...
متن کاملVariable-focus liquid lens.
A variable-focus liquid lens using a transparent flat cell is demonstrated. The top substrate has an aperture which is sealed with a thin elastic membrane on the outer surface and the bottom aperture is sealed on the inner surface of the bottom substrate. By applying a pressure to the outer membrane inward causes the liquid to redistribute and swell the inner membrane outward which, in turn, fo...
متن کاملRetroviral expression of connexins in embryonic chick lens.
PURPOSE To develop an in vivo model system in which exogenous proteins can be expressed in embryonic chick lens and to further understand the function of connexin-mediated gap junction intercellular communication in lens cell biology. METHODS RCAS(A) is a replication-competent chicken retrovirus that infects dividing cells. Retroviral constructs were prepared containing alkaline phosphatase (...
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ژورنال
عنوان ژورنال: BMC Cell Biology
سال: 2017
ISSN: 1471-2121
DOI: 10.1186/s12860-016-0116-6